More data on alirocumab and diabetes risk
I happened to see an abstract from the American Heart Association Scientific Sessions in which the authors slice and dice the alirocumab data to see if they could find effects on development of diabetes or impaired glucose control in patients without diabetes at baseline. As you can see in the table below, there are some numerical differences in (1) patients with normal blood sugar at baseline who developed impaired glucose control and (2) patients with impaired glucose control who developed diabetes. The differences were not statistically significant. No resolution of this issue is likely until the results of the outcomes trials are available. See my previous post on this here.
Posted on December 8, 2015, in cardiology, drug safety and tagged alirocumab, blood glucose, cholesterol, diabetes, heart disease, impaired glucose control, PCSK9 inhibitors. Bookmark the permalink. Leave a comment.